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(R)-Zelebrudomide, also known as (R)-NX-2127, is an isomer of the BTK PROTAC degrader Zelebrudomide. It is used in cancer research and is supplied as a light yellow to yellow solid with a purity of 98.93%. This product is for research use only and has not been fully validated for medical applications.
Isomer of BTK PROTAC degrader Zelebrudomide
Used in cancer research
Supplied as a light yellow to yellow solid
Purity of 98.93%
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(R)-NX-2127 is the R-isomer of a Bruton's tyrosine kinase (BTK) PROTAC degrader supplied as a high-purity solid for preclinical research. The compound is intended for use in studies of BTK degradation and related cellular pharmacology; consult the supplier product page and SDS for handling and storage details.
R-isomer of a BTK PROTAC degrader
High reported purity (98.93%)
Molecular weight 719.83
Chemical formula C39H45N9O5
Solid, light yellow to yellow appearance
Recommended storage: 4°C protected from light; in solvent -80°C (6 months) or -20°C (1 month)
Intended for preclinical BTK degradation and cellular assays
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Captopril disulfide is the symmetrical disulfide metabolite of captopril provided as a research/analytical standard with reported antihypertensive activity via angiotensin-converting enzyme inhibition. The compound is supplied in multiple small pack sizes for laboratory use.
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N N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain reproductive organ weight and multiple reproductive and developmental indicators in rats
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2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium and exhibits anti-Candida albicans activity. Diclofenac Sodium is described as a potent and nonselective anti-inflammatory agent that acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
Analogue of Diclofenac Sodium.
Exhibits anti-Candida albicans activity.
Potent and nonselective anti-inflammatory agent.
Acts as a COX inhibitor.
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Bis(2-methyl-3-furyl)disulfide, compound (2), is a flavoring compound designed to enhance the natural, fresh, and milk-rich feeling of milk-related products. It is for research use only and not sold to patients.
Enhances natural feeling of milk-related products.
Enhances fresh feeling of milk-related products.
Enhances milk-rich feeling of milk-related products.
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Zelebrudomide (NX-2127) is an orally active PROTAC degrader that targets Bruton's Tyrosine Kinase (Btk). It inhibits the proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib and appears as a light yellow to yellow solid. The compound has a molecular weight of 719.83.
Targets Bruton's Tyrosine Kinase (Btk)
Inhibits the proliferation of BTKC481S mutant TMD8 cells
Catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3)
Stimulates T cell activation
Increases IL-2 production in primary human T cells
Demonstrates potent degradation of BTK in cynomolgus monkeys in vivo
Leads to superior tumor growth inhibition in both WT TMD8 and C481S mutant xenograft models in mice
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CSTSMLKAC (peptide 2) is a cyclic 9 amino acid sequence that mimics endogenous peptide sequences. CSTSMLKAC homes to cardiomyocytes in the ischemic myocardium.
Cyclic 9 amino acid sequence
Mimics endogenous peptide sequences
Homes to cardiomyocytes in the ischemic myocardium
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